Adverse effects of alcohol illegal drugs and steroid usage on the human body

In the laboratory classroom clinical trials in children (Studies 1 and 2), both CONCERTA® once daily and methylphenidate three times daily increased resting pulse by an average of 2 to 6 bpm and produced average increases of systolic and diastolic blood pressure of roughly 1 to 4 mm Hg during the day, relative to placebo. In the placebo-controlled adolescent trial (Study 4), mean increases from baseline in resting pulse rate were observed with CONCERTA® and placebo at the end of the double-blind phase (5 and 3 beats/minute, respectively). Mean increases from baseline in blood pressure at the end of the double-blind phase for CONCERTA® and placebo-treated patients were and mm Hg (systolic) and and mm Hg (diastolic), respectively. In one placebo-controlled study in adults (Study 6), dose-dependent mean increases of to bpm from baseline in standing pulse rate were observed with CONCERTA® at the end of the double-blind treatment vs. an increase of beats/minute with placebo. Mean changes from baseline in standing blood pressure at the end of double-blind treatment ranged from to mm Hg (systolic) and to mm Hg (diastolic) for CONCERTA® and was mm Hg (systolic) and - mm Hg (diastolic) for placebo. In a second placebo-controlled study in adults (Study 5), mean changes from baseline in resting pulse rate were observed for CONCERTA® and placebo at the end of the double-blind treatment ( and - beats/minute, respectively). Mean changes from baseline in blood pressure at the end of the double-blind treatment for CONCERTA® and placebo-treated patients were - and - mm Hg (systolic) and and mm Hg (diastolic), respectively [see WARNINGS AND PRECAUTIONS ].

Adverse effects of alcohol illegal drugs and steroid usage on the human body

adverse effects of alcohol illegal drugs and steroid usage on the human body

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