Antiinflamatoare steroidiene generalitati

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Clinical Editor's comments (September 2017)
Dr Hayley Willacy would like to make you aware that people with moderate to severe plaque psoriasis can now receive dimethyl fumarate (Skilarence®) as a licensed oral treatment option for those needing systemic therapy [ 19 ]  . It can be prescribed as first-line induction therapy and long-term maintenance treatment. Dimethyl fumarate as Fumaderm® is already used as an unlicensed product in the UK. The anti-inflammatory and immunomodulating effects of dimethyl fumarate are not fully understood but are thought to involve a shift in T helper cells from the Th1 and Th17 phenotypes to the Th2 phenotype, with a resultant decrease in the production of inflammatory cytokines and inhibition of keratinocyte proliferation.

The first sulfonamide and the first systemically active antibacterial drug, Prontosil , was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany, [35] [39] [33] for which Domagk received the 1939 Nobel Prize in Physiology or Medicine. [40] Sulfanilamide, the active drug of Prontosil, was not patentable as it had already been in use in the dye industry for some years. [39] Prontosil had a relatively broad effect against Gram-positive cocci , but not against enterobacteria . Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials. [41] [42]

Antiinflamatoare steroidiene generalitati

antiinflamatoare steroidiene generalitati


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