Investigation to detect a possible sensitizing effect of Scheriproct or of the active ingredients contained therein has not been carried out. According to relevant data gained from spontaneous reports as well as contained in the literature, it is possible that not only individual ingredients of the formulation base but also the active ingredients themselves are responsible for the allergenic skin reactions which were observed only sporadically after the use of Scheriproct. There is, however, no risk of a sensitizing effect occurring other than in sporadic cases.
Microbiology: The anti-infective components in CORTISPORIN Ophthalmic Ointment are included to provide action against specific organisms susceptible to it. Neomycin sulfate and polymyxin B sulfate are active in vitro against susceptible strains of the following microorganisms: Staphylococcus aureus, streptococci including Streptococcus pneumoniae , Escherichia coli , Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa . The product does not provide adequate coverage against Serratia marcescens (see INDICATIONS ).