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In the 1860s, descriptions of boys who grew progressively weaker, lost the ability to walk, and died at an early age became more prominent in medical journals. In the following decade, [34] French neurologist Guillaume Duchenne gave a comprehensive account of the most common and severe form of the disease, which now carries his name—Duchenne MD. It soon became evident that the disease had more than one form. [35] The other major forms are Becker, limb-girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, distal, and EDMD. [9] Duchenne and Becker muscular dystrophies, being caused by a mutation of a gene located on the X chromosome, predominantly affect males, although females can sometimes have severe symptoms, as well. Most types of MD are multisystem disorders with manifestations in body systems including the heart, gastrointestinal system, nervous system, endocrine glands, eyes, and brain. [9]

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