Funcion general de los esteroides

Issue (and what should be considered) Recommended process Quality of evidence Strong recommendations usually require at least moderate-quality evidence for all the critical outcomes. The lower the quality of evidence, the less likely there should be a strong recommendation. Relative importance of the outcomes
(benefits, harms, burdens) Authors and editors consider the relative values and preferences that patients and other stakeholders place on outcomes and the variability in values and preferences across patients. If values and preferences vary widely, a strong recommendation becomes less likely. Baseline risks of adverse outcomes
(typically most relevant for benefits) The higher the baseline risk of an adverse outcome, the greater the magnitude of benefit a treatment will offer, and the more likely there should be a strong recommendation. If the baseline risk is very different for two subpopulations, then UpToDate may make separate recommendations for these different groups. Magnitude of effect (benefits - eg,
reduction in RR; harms - eg, increase in RR; burden) Larger relative risk reductions with treatment make a strong recommendation for treatment more likely, while larger increases in the relative risk of harms make a strong recommendation for treatment less likely. Absolute magnitude of the effect (benefits,
harms, burden) The larger the absolute benefits with treatment, the greater the likelihood of a strong recommendation in favor of treatment. The larger the absolute increase in harms, the less likely there should be a strong recommendation in favor of treatment. Precision of the estimates of the effects
(benefits, harms and burdens) The greater the precision, the more likely there should be a strong recommendation. Cost The higher the incremental cost, the less the likelihood of a strong recommendation in favor of a treatment.

Funcion general de los esteroides

funcion general de los esteroides

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