Based on the one-on-one interactions Butters and Jimmy have had on the show, they seem to be good friends. In " Krazy Kripples ," Butters was the only person who went to see Jimmy's comedy show instead of Christopher Reeve's public appearance. In " Erection Day ," Jimmy came to Butters for advice on his erection problems, expressing that Butters is the only one he can tell who won't make fun of him for it. The two were also seen sitting together at Cartman's AIDS benefit in " Tonsil Trouble ". During Season Fifteen's episode " 1% " Jimmy and Butters form the 99% club to protest the Presidential Fitness Test results. They stand outside and picket the President's Council on Fitness, Sports & Nutrition, Colorado Division Regional Office, only the media believe they are protesting the Red Robin Restaurant. In " Funnybot ," Butters is the only person in the audience who was clapping and cheering Jimmy while everybody else was asleep. In " Going Native ," Butters reveals that he doesn't find Jimmy's jokes funny. In " A Nightmare on Face Time ," the two are seen trick-or-treating together.
Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.