The show is famous as an equal-opportunity offender, frequently employing crass language, gruesome violence, and sex, and not shying away from mocking any institution or religion, including entire episodes devoted to mocking the theology of Mormons and an attack on the Church of Scientology. When Isaac Hayes, a practicing Scientologist and voice of the major(and popular)Chef character, threatened to resign the show if the Scientology spoof was aired, Parker and Stone aired it anyway, then had Chef suffer a horrible death at the hands of a devious cult in a later episode. They planned to include an image of Muhammad in an episode in the wake of the Danish cartoon controversy of 2005, but Comedy Central pulled the episode. Such incidents epitomize Parker and Stone's strong views on freedom of speech.
As Jesus vs. Santa became more popular, Parker and Stone began talks of developing the short into a television series. Fox refused to pick up the series, not wanting to air a show that included the character Mr. Hankey , a talking piece of feces.  The two then entered negotiations with both MTV and Comedy Central. Parker preferred the show be produced by Comedy Central, fearing that MTV would turn it into a kids show.  When Comedy Central executive Doug Herzog watched the short, he commissioned for it to be developed into a series.