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DHT is a potent agonist of the AR, and is in fact the most potent known endogenous ligand of the receptor. It has an affinity (K d ) of to nM for the human AR, which is about 2- to 3-fold higher than that of testosterone (K d = to nM)  and 15–30 times higher than that of adrenal androgens .  In addition, the dissociation rate of DHT from the AR is 5-fold slower than that of testosterone.  The EC 50 of DHT for activation of the AR is nM, which is about 5-fold stronger than that of testosterone (EC 50 = nM).  In bioassays , DHT has been found to be - to 10-fold more potent than testosterone.