Steroid rosacea-like facies

Dermatological vascular laser (single wavelength) or intense pulsed light (broad spectrum) machines offer one of the treatments for rosacea, in particular the erythema (redness) of the skin. [29] They use light to penetrate the epidermis to target the capillaries in the dermis layer of the skin. The light is absorbed by oxy hemoglobin , which heats up, causing the capillary walls to heat up to 70 °C (158 °F), damaging them, and causing them to be absorbed by the body's natural defense mechanism. With a sufficient number of treatments, this method may even eliminate the redness altogether, though additional periodic treatments will likely be necessary to remove newly formed capillaries. [23]

Prednisolone is primarily eliminated by hepatic metabolism, to approximately 70 % by glucoronidation and to approximately 30 % by sulphatation. There is also conversion to 11ß,17ß-dihydroxyandrosta-1,4-dien-3-one and to 1,4-pregnadien-20-ol. The metabolites exhibit no hormonal activity and undergo primarily renal elimination. Negligible amounts of prednisone and prednisolone are found unchanged in the urine. The plasma elimination half-life of prednis(ol)one is approximately 3 hours. In patients with severe hepatic dysfunction the half-life may be prolonged and a dose reduction should be considered. The duration of the biological effects of prednis(ol)one exceeds the duration of the presence in the serum.

Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses , as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails ). [15] [16] While only a small number of skin diseases account for most visits to the physician , thousands of skin conditions have been described. [14] Classification of these conditions often presents many nosological challenges, since underlying etiologies and pathogenetics are often not known. [17] [18] Therefore, most current textbooks present a classification based on location (for example, conditions of the mucous membrane ), morphology ( chronic blistering conditions ), etiology ( skin conditions resulting from physical factors ), and so on. [19] [20] Clinically, the diagnosis of any particular skin condition is made by gathering pertinent information regarding the presenting skin lesion (s), including the location (such as arms, head, legs), symptoms ( pruritus , pain), duration (acute or chronic), arrangement (solitary, generalized, annular, linear), morphology ( macules , papules , vesicles ), and color (red, blue, brown, black, white, yellow). [21] Diagnosis of many conditions often also requires a skin biopsy which yields histologic information [22] [23] that can be correlated with the clinical presentation and any laboratory data. [24] [25] [26]

Oral and topical antibiotics are often ineffective in the treatment of erythema and flushing. The most effective way to prevent the occurrence of flushing episodes and the progression of the disease is to avoid the associated trigger factors. Low-dose clonidine (Catapres; mg twice daily) may be effective in controlling flushing, especially in women who are postmenopausal. 18 A nonselective beta blocker (such as long-acting propranolol [Inderal], 80 to 240 mg daily, and nadolol [Corgard], 40 to 80 mg daily) may also be used to treat erythema and flushing. 18

Steroid rosacea-like facies

steroid rosacea-like facies

Oral and topical antibiotics are often ineffective in the treatment of erythema and flushing. The most effective way to prevent the occurrence of flushing episodes and the progression of the disease is to avoid the associated trigger factors. Low-dose clonidine (Catapres; mg twice daily) may be effective in controlling flushing, especially in women who are postmenopausal. 18 A nonselective beta blocker (such as long-acting propranolol [Inderal], 80 to 240 mg daily, and nadolol [Corgard], 40 to 80 mg daily) may also be used to treat erythema and flushing. 18

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